Granger, Dr. Christopher

Biography

Dr. Chris Granger is an Associate Professor of Medicine and Director of the Cardiac Care Unit at Duke University Medical Center.

Dr. Granger received his BA in 1980 and graduated Cum Laude from Middlebury College in 1980. He received his MD from the University of Connecticut School of Medicine in 1984. He continued his medical training at the University of Colorado, where he completed an internship and residency in Internal Medicine. He received the housestaff teaching award and served as Chief Resident. Dr. Granger then proceeded to Duke University where he completed his Fellowship in Cardiology in 1990, when he joined the faculty staff in the Division of Cardiology. Dr. Granger is a Diplomat of the American Board of Internal Medicine as well as being Cardiovascular Board Certified. Dr. Granger is a Fellow of the American College of Cardiology and of the European Society of Cardiology.

His primary research interest is in conduct and methodology of large randomized clinical trials in heart disease. His major activity has been in trials involving acute ischemic heart disease and heart failure. This includes coordination of the Duke Clinical Research Institutes’ activities in the ASSENT-4, OASIS-5 and 6, and ACTIVE trials evaluating treatments for acute myocardial infarction, acute coronary syndromes, and atrial fibrillation. He is cochairman of the APEX-AMI trial studying an inhibitor of complement to reduce mortality. He serves on the executive committee of the CHARM trial that studied an angiotensin receptor blocker in chronic heart failure, and ongoing CHARM activities include chairing the genetics substudy.

He has served on the Steering Committees of GUSTO I, II, III and IV, PARAGON, HERO-2, ASSENT-2, ASSENT-3, ASSENT-3 Plus, ASSENT-4, CARDINAL, SYMPHONY, ACTIVE, OASIS-5 and -6, CHARM, and APEX-AMI studies. He also is a member of the GRACE and CATCH Registry and the GENECARD Steering Committees. He co-chairs the Reperfusion in Carolina Emergency Department (RACE) project and is a member of the ACC Door-to-Balloon initiative. He directs a large project addressing proteomics, gene expression, and metabolomics of coronary heart disease. He has served on numerous data safety monitoring boards.

His government-sponsored research activities include the DCRI Cardiovascular CERT Research Center, the GENECARD study, the BARI 2D trial, and the National Human Genome Research Institute Comparative Approach to Genomics of Complex Traits, for which he serves as a consultant. He recently co-chaired NHLBI working groups on clinical proteomics and cell-based therapies for cardiovascular disease.

Based on his research, Dr. Granger has contributed a total of over 300 articles, abstracts, book chapters, and invited publications. He currently serves as Associate Editor for the American Heart Journal and is on several editorial boards including the Journal of the American College of Cardiology and European Heart Journal.

Presentations:

New Anti-Thrombotic Therapy in ACS: Practice Implications (2 MB)

Importance of Bleeding and Transfusions in ACS (2 MB)